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The Promise of Neuralink in Shaping Our World

Aly Gajani
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The Promise of Neuralink in Shaping Our World

If you find the abilities of Doctor Octopus interesting, then there’s promising news: that reality is closer than you might think. Imagine a world where individuals like the character Doc Ock from Spider-Man can control prosthetic limbs effortlessly with their minds. What if your forgotten memories can be accessed naturally or learning a new language becomes as easy as downloading an app? Once confined to fiction, this futuristic concept can become achievable with advancements like Neuralink’s Brain-Computer interface.

Our brains are like natural electronic devices. Every move we make, every thought we have, is powered by electrical signals coursing through our nerves. When you move your arm to the right, specific sets of neurons are activated in a particular pattern. By using neuro-electrophysiological recording, a process that measures the electrical activity of neurons, we can quickly predict the direction in which the arm will move. 

By using electrodes, we can capture and transmit these signals, which theoretically have the potential to enhance or restore brain function. This is the fundamental idea behind a brain-computer interface (BCI): a system that allows a person to control an external device using brain signals. 

One of the most anticipated breakthroughs in Brain-Computer Interfaces (BCIs) comes from a company known as ‘Neuralink.’ Founded in 2016 by the visionary billionaire Elon Musk, Neuralink’s mission is to pioneer implantable chips within the human skull that will enable the user to control devices and help people with severe motor impairments seamlessly.

Musk has famously expressed concerns about the potential dangers of uncontrolled artificial intelligence. He stated that merging with AI through technologies like Neuralink is crucial for humans to remain relevant and avoid being surpassed by artificial intelligence. However, what exactly is the technology that Neuralink has initiated human trials on, why is it noteworthy, and what ethical considerations does it entail? All of these questions will be addressed in this article.

Monkey Playing ‘Pong’ Using Only Its Brain Source: Neuralink
Monkey Playing ‘Pong’ Using Only Its Brain Source: Neuralink

Company’s Progress

In the initial stages, Neuralink focused on designing and testing electrodes that could record and stimulate brain activity. Over the years, they tested their devices through surgical implantation in various animals, such as monkeys and pigs. In April 2021, Neuralink displayed a significant advancement when a monkey demonstrated the ability to play the game “Pong” using the Neuralink implant. This breakthrough highlighted the potential for direct neural control of external devices.

Fast forward to May 2023, Neuralink achieved a major milestone as it received approval for human trials in the United States. Following this approval, in September 2023, the company initiated its first human trials, focusing on individuals with quadriplegia due to cervical spinal cord injury or amyotrophic lateral sclerosis (ALS).

On January 29, 2024, Elon Musk made an exciting announcement about a significant breakthrough. They successfully implanted a device in a human participant, marking a significant milestone. Musk expressed his optimism in a tweet, mentioning that the patient is recovering well and the results indicate promising neuron spike detection. 

Exploded view of Neuralink's implant with the N1 chip. Source: Neuralink
Exploded view of Neuralink’s implant with the N1 chip. Source: Neuralink

A Look at Neuralink Brain Chip Technology 

Brain-computer interfaces (BCIs) have been around since the 1990s, and now several companies are developing their own versions. Two major competitors for Neuralink are ‘Synchron’ and ‘Blackrock Neurotech’. The New York-based company Synchron is focused on developing an endovascular BCI device that can access every part of the brain using the blood vessels. On the other hand, ‘Emotiv’ offers removable EEG headsets that enable users to control virtual objects and interfaces through brainwave patterns and averaged signals produced by populations of neurons.

However, what sets Neuralink’s N1 implant apart and makes it unique is that, unlike others, their device is implanted directly inside the skull. This allows the electrodes to touch the brain surface directly, enabling the device to target the activity of individual neurons. According to neuroscientists, this level of precision is necessary for sophisticated thought decoding. Additionally, the N1 implant is completely wireless, offering greater flexibility and convenience for users. This has never been done before, and scientists are eagerly anticipating its real-world usage.

Neuralink calls its device the N1-Chip, which is comprised of a probe. The probe, made primarily of polyimide (a biocompatible material) with a thin gold or platinum conductor, is inserted into the brain using an automated process carried out by a surgical robot. Designed specifically to insert multiple flexible probes rapidly and precisely into the brain, minimizing tissue damage. 

Each probe has a wire section containing electrodes that can detect electrical signals in the brain, as well as a sensory area where the wire connects with an electronic system for amplifying and capturing the brain signal. While current technology limits the device to recording groups of neurons rather than individual ones, Neuralink’s ultimate goal is to decode neural information into a binary code, enabling a deeper understanding of brain function and the potential to stimulate neurons for therapeutic purposes. 

Significance and Applications 

But you might be wondering, how does all this fancy technology make a difference in our everyday lives? Well, beyond just being a marvel of engineering, Neuralink can change lives and reshape how we interact with the world around us.

It has an obvious application – to assist individuals with severe motor impairments in communicating and operating devices using their thoughts. This has the potential to significantly impact the lives of people with conditions like paralysis, granting them a newfound sense of independence and control over their surroundings. 

According to the World Health Organization (WHO), approximately 15% of the global population (around 1.3 billion people) is affected by some kind of disability, with 2-4% experiencing significant challenges in their daily functioning (WHO, 2011). If Neuralink completes its human trials, it could significantly improve the lives of many individuals.

Neuralink is already envisioning its device to enhance human cognitive abilities, such as memory, attention, and problem-solving. A member of the visual neuroscience team at Neuralink shared that this project could offer a groundbreaking solution for individuals with retinal injury or blindness caused by eye trauma. 

The essential plan involves directly connecting a camera to the visual cortex and using several thousands of electrodes to generate a visual image. In the future, this can potentially lead to superhuman vision, seeing the world in various wavelengths like ultraviolet or infrared light and radar. Cognitive disorders like dementia and blindness can be easily dealt with.

There is still a lot of uncertainty about how practical these applications are at the current stage of technological development. However, even if these advancements are difficult to achieve, Neuralink can still be incredibly valuable for studying the brain’s neural activity. This research has the potential to reveal important insights into consciousness and cognition. 

“The side effect of this device is, you’ll end up learning a ton about how the brain works,” said one of the team members.

Public perception and reviews. Source Neuralink
Public perception and reviews. Source Neuralink

Understanding Concerns and Public Perception 

While we should remain optimistic for a futuristic world, the possibilities mentioned above are still miles down the road, even over the next hill. The initial human trials ‘prime study’ is expected to last around six years, and the FDA will closely monitor the progress to ensure compliance with regulatory standards and guidelines. Furthermore, several factors could potentially impact the realization of these possibilities, such as ethical considerations, regulatory approvals, and societal acceptance.

Firstly, one of the major problems with Neuralink is the lack of published data supporting its technology. Even though they have conducted various experiments and worked on perfecting the design of the chip, much of the detailed data and results from these efforts have not been made publicly available in peer-reviewed journals. 

During a conversation with CBC News, Dr Judy Illes, an expert in neurology, expressed that the lack of transparency equates to a lack of scientific rigor at this point. Secondly, the public is concerned about Elon Musk’s ability to effectively safeguard sensitive data obtained from participants in clinical trials, given Twitter’s previous mishandling of data and breach of their commitment to protect user rights. 

The company has also faced scrutiny and controversy over alleged animal cruelty, including accusations of violating the federal Animal Welfare Act. Reuters reported that over 1,500 animals have died during Neuralink’s experiments since its beginning in 2018. There are also reports of a large number of primates being euthanized after undergoing medical trials. According to employees, Musk exerted significant pressure on the staff to expedite animal trials, potentially leading to flawed experiments. 

The FDA rejected the application for human trials a few times before granting the green light for limited human testing under strict conditions. One major concern was the surgical process involved in implanting the chip. While the implant itself is small, the procedure still entails brain surgery, raising concerns about potential complications such as bleeding, infection, and damage to brain tissue over time. 

Moreover, there is concern about the possibility of the device interfering with the brain’s natural signaling patterns and the potential risk of components migrating to other areas of the brain. 

Public opinion of Neuralink varies greatly, reflecting different views on the potential benefits and ethical implications of brain-computer interface technology. Some people are skeptical, pointing to Elon Musk’s history of making grand promises and not delivering on time. For example, a Reddit user named ‘Amazing_Ad7386’ commented, “Elon’s companies have a poor track record of overpromising (especially in delivery time) and underdelivering.”

Similarly, a 2021 survey conducted by the Pew Research Center found that Americans are divided on the widespread use of brain chips. While 63% expressed concerns, viewing it as “meddling with nature” and crossing moral boundaries, 35% embraced the idea as a way to advance humanity.

A Twitter user named ‘Stormrobinson’ expressed similar opinions, saying, “It’s a true feat of engineering and monumental human achievement — but there’s no way I’m letting someone drill a hole in my head to install a computer. I’ll probably have to pay a monthly fee to use.”

These responses highlight the complex ethical, societal, and practical considerations surrounding Neuralink’s technology and its integration into everyday life. As discussions continue, it will be essential to address public concerns and promote transparency in order to foster wider acceptance and understanding of brain-computer interfaces. 

Ultimately, the future of Neuralink holds immense potential in advancing neuroscience and human augmentation, offering hope for a future where technology enhances our lives while respecting our values and ethics.

  1. Sagar, R. (2020, September 19). Ten mind-bending applications of Neuralink, according to the team. Analytics India Magazine. https://analyticsindiamag.com/mind-bending-applications-neuralink-event/
  2. What is Elon Musk’s Neuralink brain chip, now being tested on humans? Al Jazeera. https://www.aljazeera.com/news/2024/1/31/what-is-elon-musks-neuralink-brain-chip-now-being-tested-on-humans
  1. Torrella, K. (2022, December 11). The Elon Musk Neuralink animal cruelty allegations, explained. Vox. https://www.vox.com/future-perfect/2022/12/11/23500157/neuralink-animal-testing-elon-musk-usda-probe
  1. UN World Health Organization (WHO), World Report on Disability: Summary, WHO/NMH/VIP/11.01, 2011, https://www.refworld.org/reference/annualreport/who/2011/en/89207 

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The Challenges of Pakistani Parents of Autistic Children: A Double-edged Sword

Adeel Saeed
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The Challenges of Pakistani Parents of Autistic Children: A Double-edged Sword

On February 16, 2024, Syed Arsalan Hashmi, an engineer from the Bannu district of Khyber Pakhtunkhwa, welcomed his first child, a cute baby boy. The couple named him Azlan and got fully engaged in caring for their son. 

“Life was going smooth, and our son was growing normal with expressing his liking for different things but was unable to start talking,” relates Arsalan. He used to say single words, and we hoped he would start talking over time. 

While recollecting childhood memories of Azan, Arsalan Hashmi said he used to speak the names of things like car, cat, candy, etc., but could not express his feelings. Azan’s inability to start chatting even on his third birthday made his parents deeply concerned, and they decided to take the child to doctors for check-ups.

Medical practitioners diagnosed Azan with Autism Spectrum Disorder (ASD), a complex neuro-developmental disorder that affects a child’s communication, socialization, and cognition. The diagnosis of neurological disease was nothing more than a bombshell for both Arsalan and his spouse, which turned their sentiments of contentment into feelings of deep gloom and worry.

Parent’s woes due to lack of treatment facilities for autistic children 

“Our distress was exacerbated manifold when we came across that no pediatrician in Bannu can treat artistic children, and we have to take Azan to big cities for rehabilitation through `Applied Behavior Analysts (ABA).”

The desperate parents found an Autism center in Karachi and rushed there with the hope of getting him cured. Arsalan used to take Azan four times a month to Karachi from Bannu for therapies. After six months of extensive traveling, he gave up due to enormous physical exertion for both the father and son and a substantial financial burden. 

After a little pause, Arsalan took Azan to an autism center in Lahore. The Lahore Autism Center was a public sector entity catering to a large number of patients from Punjab; Arsalan realized after a few visits that his son could not get proper treatment there due to limited examination by therapists. 

Meanwhile, a privately run Talha Autism Center in Peshawar grabbed Arsalan’s attention, and he started visiting the provincial metropolis every week for a few months. Observing slight improvement in the child, Arsalan and his spouse took a bold step, leaving their spacious Bannu home and renting a Peshawar.

Twelve-year-old Muhammad Yousaf has autism and deafness. 
Twelve-year-old Muhammad Yousaf has autism and deafness. Photo, Author

“Parents of autistic children in Pakistan are caught between a rock and deep sea due to the very high cost of treatment and mental stress they endure due to lack of proper cure facilities in their hometowns,” Arsalan shared his inner sentiments.

“The life of parents with an autistic child is harrowing with huge mental toll,” said Mrs. Imran, mother of a 12-year-old child, Muhammad Yousaf, who has autism and deafness. 

Yousaf’s father lives in Dubai for employment; she migrated to Peshawar from Swabi at her parents’ home to treat her son properly at the government-run Autism Center. “My father-in-law sold his land, and I vented my jewelry for Yousaf’s treatment from Islamabad and Peshawar,” Mrs Imran informed.

Dedicated efforts and intense devotion by his mother improved severely autistic Yousaf, who has an innate inclination towards painting and is engaged in expressing his thoughts by spreading colors on paper. Recently, some of Yousaf’s artwork was displayed in an exhibition at Peshawar University, receiving a lot of appreciation and applause from participants. 

Autistic children in underprivileged families living on God’s mercy  

The hard-to-earn parents are unable to take their kids to other cities for treatment and leave them on God’s mercy, observed Bilawal, a goldsmith by profession and father of an autistic child from the Akhora Khattak area of the Nowshera district.

Bilawal said in his hometown; he found a lot of parents getting their kids treated through traditional healing by religious Pirs and taking them to shrines. Bilawal visited different cities due to the lack of autism treatment facilities in his hometown and finally got his son Mohammad Momin admitted to an Autism Center in Peshawar.  

“I take my son three days a week to Peshawar from Akharo Khattak in a privately hired transport service,” shared Bilawal. “The expenses incurred on treatment are beyond my earnings, and I have been burdened with substantial financial debt during the last few years.”

“Lack of cost-effective treatment service for disadvantaged families having children with autism is pushing the patients toward the severity of the illness. They have attacks of aggression, head banging, self-biting, yelling, and confining in seclusion,” observed Muhammad Bilal, Managing Director of Talha Autism Center Peshawar.   

Number of Autistic children in Pakistan  

According to a study published in September 2023 in the International Journal of Surgery Global Health, no reliable data on the prevalence of ASD in Pakistan is available, as individuals with psychiatric disorders resist going to health professionals due to social stigma, leading to a low number of case reports failing to receive proper care from professionals.

However, the Pakistan Autism Society, while quoting some statistics from South Asia, estimated in 2020 that about 350,000 children have ASD in Pakistan.

A picture of autistic children during a collective activity at Talha Autism Centre in Peshawar.
A picture of autistic children during a collective activity at Talha Autism Centre in Peshawar. Photo, Author.

The plight of autistic patients in Khyber Pakhtunkhwa

Several factors have been identified that cause a child to be more likely to have ASD, including environmental, biological, and genetic factors. Experiencing complications at birth or having certain genetic or chromosomal conditions, such as fragile X syndrome or tuberous sclerosis, also causes autism among children. Consanguineous marriage and inter-family marriages are also some genetic factors that contribute to causing autism in children.

According to estimates, there are around 150,000 artistic children in Khyber Pakhtunkhwa who are in dire need of treatment from qualified therapists, observed Dr. Maheen Khattak, an experienced therapist who is the first ever and the only Board Certified Behavior Analyst (BCBA) in KP with additional qualification of Registered Behavior Therapist (RBT) from the US.

“After experiencing the illness of my daughter, I made it a life mission to serve children who have autism. In 2019, I set up a clinic at my home in Peshawar, named `Autism Jewel’,” Maheen told Scientia Pakistan. 

“Realizing the increase in the number of children with ASD, the Khyber Pakhtunkhwa government, through the Social Welfare Department, set up an Autism Center in Peshawar to provide cures on free of cost basis,” informs Rizwan Ahmad, Project Director Center for Excellence for Special Children with Autism in KP. 

“The center can provide rehabilitation services to 50 children, but we have admitted around 66 patients. They are from Peshawar, Charsadda, Mardan, and even Swabi districts who visit daily, covering a long distance for treatment and therapies,” Rizwan added.

“Dozens of patients are in line, and we receive more admission applications daily. Still, we cannot accommodate all the aspirants until the rehabilitation of the already enrolled children is complete.”    

“Autistic patients are getting therapies, including Applied Behavior Analysis, Speech, Occupational, & Sensory Integration, by a staff of around 14 members, including seven psychologists, three speech therapists, three occupational therapists, and one physiotherapist.”

An autistic boy attending a physiotherapy session in Peshawar. Photo, Author
An autistic boy attending a physiotherapy session in Peshawar. Photo, Author

Certified therapists deficiency complicating treatment of autism patients

“Acute paucity of treatment of autism in Khyber Pakhtunkhwa through certified therapists could be gauged from the fact that the government-run Center of Excellence for Special Children with Autism in Peshawar is the only rehabilitation center, functioning under the observation of a qualified BCBA (Board Certified Behavior Analyst),” disclosed Ms. Rutaba, Speech Therapist. 

Serving at the government-run Autism Center in Peshawar, Rutaba said the majority of private rehabilitation centers lack facilities of quality treatment through certified therapists but are functioning and charging enormous amounts from parents.  

In Khyber Pakhtunkhwa, there is no such rehabilitation center for the cure of adolescents with autism, while the majority of private centers are admitting elderly autistic patients and receiving treatment charges, claims Maryam Jehangir, another psychologist who is also doing an online course on  International Behavior Analyst (IBA) from an American institute. Even the Center of  Excellence for Special Children with Autism in Peshawar has the facilities for rehabilitating children up to the age of 12 years and cannot provide service to adolescents, she added. 

Lack of awareness causes delayed diagnosis of autism in children 

“Early diagnosis and proper treatment could minimize adverse effects of the disease, but due to lack of awareness, parents recognize neurological disorders at later stages,” pinpointed Madam Tahira, a psychologist at Autism Center Peshawar.

She said diagnosis is also a very skillful practice, and Dr. Maheen is the only specialist in Khyber Pakhtunkhwa who can do an Autism Diagnostic Observation Schedule (ADOS-2) test for diagnosis of autism at an early stage. Due to the lack of diagnosis facilities, all the patients in Khyber Pakhtunkhwa are sent to Islamabad and Lahore for diagnosis.   

Exorbitant fees deprive parents of getting their autistic children treated at private centers 

“Parents of autistic children establish the majority of private autism centers, but unfortunately, the treatment they offer is costly and beyond the reach of the lower/ middle class. The minimum fee they demand is around 60,000 PKR (215.23$) for one month’s treatment,” laments Rizwan Ahmad, Project Director of the Center for Excellence for Special Children with Autism in KP.

The government should announce a subsidy as a token of support for those parents who cannot afford fees at private autism centers for the rehabilitation of their children, he suggested. A plan is also under consideration by the Social Welfare Department of KP to pay stipends monthly to children admitted at the Center for Excellence for Special Children with Autism.

The number of children affected by autism is rapidly increasing across the country, and this is the need of the hour to set up welfare-oriented Autism Centers, at least at the divisional level, Rizwan stressed. 

“The humanitarian organizations serving in the country should consider the hardships faced by hard-to-earn parents in getting their children rehabilitated due to the high cost of treatment and extend financial support to them,” Rizwan suggested.

EKKO Wave Therapeutic Device- A ray of hope 

A recent invention of a device, `EKKO Wave Therapeutic Device’ by a team of biomedical researchers from the National University of Science and Technology (NUST) in Pakistan, provided hope in treating developmental neuro disability. EKKO, the winner of the 2023 Better World Project Award, is a non-invasive, mobile therapy that takes concepts used for the treatment of muscles and applies them to the brain, informs Dr. Muhammad Usman Akram, who is in charge of the project. 

Taking to Scientia Pakistan, Dr. Usman said around 150 parents are using EKKO devices at home and are sharing good results in the rehabilitation of their autistic children. The price of a device used at home is around PRK 50,000 (US dollars 179), and its vibrational waves aid in the fast recovery of muscles because of their resonance with the natural frequencies of the muscle fibers. 

The EKKO improves patient access to treatment for symptoms like tongue dysarthria, motor speech aphasia/dysphasia, tongue apraxia, cerebral palsy, and eye squints. About marketing of EKKO, Dr. Usman said the NUST Technology Transfer Office is working with various departments and stakeholders and, in this connection, would also approach Autism Treatment centers in Khyber Pakhtunkhwa. 

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Love-Hate Relationship between the Gut Microbiota and the Brain

Dr. Syed Hunain Riaz
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Love-Hate Relationship between the Gut Microbiota and the Brain

People often confuse the brain with the ‘mind’. And it is, for a fact, used interchangeably. Science literature obviously recognizes nature and what constitutes the ‘mind,’ but the impact is still not enough to be cemented into the subconscious of science-acclimatized people, let alone the lay folk. The brain is generally called the mind since it contains the immense and almost limitless intricate network of neurons that perceive, process, and execute decisions. 

However, we have overlooked (for the mainstream at least) the presence of a complicated neural network within the gut wall. How this network works in synchrony with the workings of the brain and how it is affected by different influences will be discussed here. One of the influences is the presence of gut microbiota (bacteria, archaea, viruses, and fungi).

To understand this influential relationship, we must understand the hows and whys of the nervous system and Microbiota. We will find out why sayings like ‘you are what you eat’ and ‘butterflies in the stomach’ do make practical and scientific sense.

The nervous system 

The nervous system in the human body consists of central and peripheral constituents. The central part is comprised of the brain and the spinal cord. The peripheral part consists of the autonomic (ANS)(network of nerves that regulates involuntary activities in the body) and peripheral nervous system (PNS). The peripheral nervous system consists of the numerous nerves that serve the voluntary functions of muscles and arise from the brain and spinal cord. 

The enteric nervous system  (ENS) present in the gut wall from the esophagus to the anus is part of the ANS. This is an extensive meshwork of neurons embedded within the gut, approximated to be 200-600 million in number, having a bidirectional relationship with the brain (sometimes referred to as the second brain)1. Along with regulating the inherent processes of the gut, like digestion and absorption2, these neurons influence the brain’s neurochemistry.

Meanwhile, the brain regulates these neurons through this feedback loop3. This axis has been referred to as the Gut-Brain axis (GBA). However, the ‘Mind’ referred to hitherto in the article also refers to this complex whole of the brain and the enteric nervous system, emphasizing this astonishing fact that how we behave, think, and act is not only orchestrated by the brain but also by what is in our bellies.

The Microbiota (the germs within)

The human body is a ‘super-organism’. It is said to host around 1014 bacterial cells within the gut, which outnumbers the human cells by a factor of 10. The same goes for the bacterial genome in the human gut, which is estimated to be approximately 100 times more abundant in the human body than the human genome itself. The organisms and humans live together in a symbiotic relationship where the gut environment provides shelter to them, and they exercise their numerous crucial roles. Some roles include regulating the immune, metabolic, and enteric nervous systems and the synthesis of vitamins4.

In addition, these microorganisms have a role in maintaining the integrity of the epithelial gut wall. This protection is invaluable in maintaining a barrier between certain ‘bad’ organisms in the gut and the blood. To benefit us, the Microbiota requires a certain balance between the different phyla, out of which Bacteroidetes and Firmicutes make up more than 90 percent of the total load in the guts5.

In addition to the bacteria, numerous fungi are populating the gut: Saccharomyces and Candida, to name a few. These exist in an existential harmony with the bacterial colonies to produce a state of balance within the gut and throughout the body. This state of balance of ‘homeostasis’ we keep referring to hinges on the harmony within the flora of the gut in terms of numbers and function.

Consider the reverse now or ‘dysbiosis,’ where the Microbiota is disturbed, which could happen for a multitude of reasons. One could be the use of antibiotics, which, as we know, act against bacteria, and as previously mentioned, our gut is loaded with them. Then there comes the fact that whatever we eat is also eaten and processed by the flora in our gut, and they are also picky eaters for their well-being. These bacteria process food and nutrients and produce chemicals that maintain a state of balance in the gut and the body. The nervous and immune systems’ well-being depends direly on this. 

If we feed them harmful chemicals, the ‘good ones’ die out, and the ‘opportunist’ ones start increasing in number. These ‘opportunists’ render the harmonious environment redundant. Local inflammation starts to creep up, and problems of indigestion and malabsorption appear. In addition to this, the whole regulation of the enteric nervous system is dysregulated by the ‘dysbiosis’6. This will be explored later.

The human body is a ‘super-organism’. It is said to host around 1014 bacterial cells within the gut, which outnumbers the human cells by a factor of 10. The same goes for the bacterial genome in the human gut, which is estimated to be approximately 100 times more abundant in the human body than the human genome itself.

The Bi-directional link between the Brain and the enteric nervous system

The brain has a two-way highway between it and the enteric nervous system. To keep it simple, the brain feels what the gut feels, and the gut feels what the brain feels. The gut wall has a meshwork of neurons and its network, which senses even the subtlest of changes in the environment, and this is signaled to the brain, which in turn sends back signals to the gut for the effector response7. Changes in the gut can include changes in the flora, pH, or quantity/quality of food. This to-and-fro feedback loop is in addition to the local responses the ENS puts up, which include hormone/neurotransmitter secretion trying to adapt to the changing gut environment.

It is fascinating to note that the gut’s internal state profoundly affects the brain’s internal state. For example, the type of food we eat can, as we know, directly influence our moods and neurocognitive parameters through the blood after being absorbed. However, the local environment created in the gut by the foods we eat can also affect the brain state. The effector responses in the brain could be the release of or inhibition of the ‘happy’ or ‘pleasure’ hormones like serotonin and dopamine.

This results in a feedback loop whereby the state of the mind then influences how our gut acts in its functions. A depressed person is more likely to have a disturbed gastrointestinal (GI) than someone who is not. The ‘Mind’ thus is not just that chunk of fat in our skulls; it is a complex whole, with a synchronized control, between the brain and the ENS. 

Influence of Microbiota on the ‘Mind’

The gut microbiota and its role in the normal functioning of the ENS and the brain have been studied extensively over the years. The gut, where they are located, has mainly been postulated to be the primary site of pathologies that give rise to neurodegenerative diseases like Alzheimer’s, Parkinson’s disease, and autism. Metabolic diseases like diabetes mellitus and even cancers are also considered to arise because of the inflammation in the gut wall, which occurs due to dysbiosis8. The microbiota release neurotransmitters and products of their metabolism of food, like short-chain fatty acids (butyrate, propionate, and acetate).

These play vital roles in the stability of the gut blood barrier, preventing inflammation and sending positive feedback signals to the brain that ‘ all is well9. Interaction between the bacteria and their products of metabolism occurs via specific receptors, which leads to the regulation of nerve function in the ENS. This is especially relevant when, in the setting of dysbiosis, pathogenic strains of bacteria, which generally are suppressed by the ‘good guy’ bacteria, start producing toxins that trigger inflammation in the gut-blood barrier and, through the ENS, may affect brain function through the feedback loops previously mentioned.

It has been shown in mouse models that microbiota-ENS interaction may facilitate CNS development during early years. This is evidenced by abnormal ENS architecture in mice made ‘germ-free’ mice, in whom reduced neuron density was also noted in studies10. Neuroactive molecules regulate nerve signals and affect neuropsychiatric parameters such as sleep, mood, and cognition. Chemicals (i.e., dopamine, serotonin, etc.) related to mood in different critical areas of the brain are regulated by the Microbiota of the gut7. One example which deserves mention here is the condition called ‘Irritable bowel syndrome (IBS)’.

Microorganisms_within_the_gut_photorealistic.
Microorganisms within the gut are photorealistic. Photo Dr. Hunain Riaz

A condition of increased gut sensitivity to pain, which may or may not be associated with altered bowel habits and function. It has been shown that stress, especially early life stress, can predispose one to this condition. It has been demonstrated in rats that the Hypothalamic-pituitary-adrenal axis, when activated during stress (can be due to cytokines or external factors), releases cortisone, which leads to a change in the Microbiota and release of neurotransmitters in the gut, which alter gut movements.

This, in turn, creates a positive feedback loop whereby more cortisone is produced and more changes in the gut environment. The lack of certain bacteria in the Microbiota has been shown to predispose to depression/anxiety. This mechanism has been observed in depression/anxiety models of rat studies, which highlights the complex processes behind IBS7. Administration of certain bacteria, antidepressants, and cognitive behavioral therapy (CBT )11 can mitigate the exaggerated cortisone response and also, hence, the whole cascade. 

Practical implications

It is quite evident that a healthy microbiota profile is essential to maintain the integrity of the ENS and its connections with and influence on the brain. In lieu of the said, maintaining a balanced & healthy lifestyle cannot be overemphasized.  This includes living a life where stress is adequately managed, getting good quality sleep, and eating a balanced diet, which includes a generous amount of pre- and pro-biotics. Prebiotics are basically foods that contain high-quality fiber, which serves as food for the ‘good guy’ bacteria in our gut.

It would make sense to increase the number of the density of these by serving them the food they need. Examples include apples, bananas, onions, asparagus, etc. Probiotics, on the other hand, are live microorganisms that, when added to our diet, can naturally increase the number and diversity of microbiota and impart health benefits. Examples include mostly fermented foods (where bacteria and yeast convert carbohydrates into acids or alcohol) such as sour cheese and cream and dark chocolate, etc.

What is important to note is that foods like yogurt that are commercially available may not actually have the bioavailable probiotics mentioned due to the processes of heat treatment, preservatives, and sugar additives. ‘Kefir’ yogurt (a variety made from milk that is fermented longer than the usual yogurt) has three times more probiotics than traditional yogurt, especially more ‘live’ cultures.

Our guts play a central part in the nexus of neural control of our very beings, so next time you go shopping for food, remember, it is not only your gut that you will serve; it is your mind!

References:

  • J.B. Furness, B.P. Callaghan, L.R. Rivera, H.J. Cho
  1. The enteric nervous system and gastrointestinal innervation: integrated local and central control.Adv. Exp. Med. Biol., 817 (2014), pp. 39-71
  2. Fleming MA 2nd, Ehsan L, Moore SR, Levin DE. The Enteric Nervous System and Its Emerging Role as a Therapeutic Target. Gastroenterol Res Pract. 2020 Sep 8;2020:8024171. doi: 10.1155/2020/8024171. PMID: 32963521; PMCID: PMC7495222
  3.   M.J. Caycho Salazar F, Herrera-Covarrubias D, A. Coria-Ávila G, I. García-Hernández L, Rebeca Toledo-Cárdenas M, Elena Hernández-Aguilar M, et al. The Brain-Like Enteric Nervous System [Internet]. Topics in Autonomic Nervous System. IntechOpen; 2023. Available from: http://dx.doi.org/10.5772/intechopen.112571
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Unveiling the Mystery: Antimatter Dances with Gravity

Amna Fatima
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Unveiling the Mystery: Antimatter Dances with Gravity

Antimatter, the unusual counterpart to ordinary matter, has captivated the minds of physicists and science enthusiasts. In 1928, when Paul Dirac was finding an equation to describe the behaviour of electrons, now known as the Dirac equation, he predicted two possibilities, one positive and one negative, similar to how a quadratic equation has two answers.

He didn’t leave out the other answer; instead, he called it the anti-electron (now known as the positron). In 1932, Carl David Anderson confirmed Dirac’s predictions when he discovered the positron by observing the tracks of cosmic ray particles in a cloud chamber.

One of the most intriguing aspects of antimatter is its behaviour under the influence of gravitational force. If we drop an ordinary book from a height, thanks to Isaac Newton, we know it will fall, but what if that book was made of antimatter? Existing theories state that antimatter behaves opposite to ordinary matter but not under the influence of gravity, but is this correct?

Will an anti-book fall or go upward? To better understand this and the beginning of our universe, we will delve into the perplexing properties of antimatter when subjected to the gravitational forces that shape the cosmos.

We first need to grasp the fundamental nature of antimatter to fathom the properties of antimatter in gravity’s presence. Antiparticles like antiprotons and positrons are mirror images of their counterparts with opposite charges and magnetic moments. For example, in the standard model, a proton contains two up quarks and one down quark, whereas an antiproton has two anti-up quarks and one anti-down quark.

Similarly, a positron (an anti-electron) has a positive charge, unlike an electron with a negative charge. Small amounts of antimatter travel down on the Earth through cosmic rays. Still, they are minute compared to the amount of normal matter, so scientists need to make them in a laboratory to study antimatter.

In the standard model, a proton contains two up quarks and one down quark, whereas an antiproton has two anti-up quarks and one anti-down quark.
In the standard model, a proton contains two up quarks and one down quark, whereas an antiproton has two anti-up quarks and one anti-down quark.

 One of the places where this happens is at CERN (European Council of Nuclear Research), the most extensive laboratory in the world for particle physics research located near Geneva at the border between Switzerland and France. The scientists here create antihydrogen atoms by binding negatively charged antiprotons, generated and decelerated in the Antimatter Factory’s AD and ELENA (Extra Low Energy Antiproton ring) machines, with positively charged positrons collected from a sodium-22 source.

When antimatter comes into contact with ordinary matter, it annihilates, resulting in a huge release of energy. This reaction is shown by Einstein’s famous mass-energy equivalence equation below:

E=mc2

This interaction raises questions about how antiparticles behave under gravity.

 Now, let us talk about whether antimatter would fall or go up under the influence of gravity. According to Einstein’s general theory of relativity, gravity is a curvature of space-time; therefore, matter and antimatter should behave similarly. Thus, existing theories assumed that antimatter, although opposite to ordinary matter, would fall under gravitational force. However, as Jeffrey Hangst said, “In physics, you don’t really know something until you observe it.”

Scientists at Stanford University tried an experiment in 1968 that attempted to measure the free fall of positrons. In the end, a trial experiment with electrons showed that environmental effects interfered with the effect of gravity, and the final experiment was not executed. Recent technology and CERN’s ELENA machine construction have been experimented with at the Antiproton Decelerator (AD) in the Antimatter Factory.

Current projects like ALPHA (Antihydrogen Laser Physics Apparatus), AEgIS (Antihydrogen Experiment: Gravity, Interferometry, Spectroscopy), and GBAR (Gravitational Behavior of Antimatter at Rest Experiment) are working on research on antimatter and its properties.

CERN launched the ALPHA Experiment, which is a cutting-edge scientific endeavour designed to explore and understand the properties of antimatter, particularly antihydrogen.
CERN launched the ALPHA Experiment, a cutting-edge scientific endeavour designed to explore and understand the properties of antimatter, particularly antihydrogen.

CERN launched the ALPHA Experiment, a cutting-edge scientific endeavour designed to explore and understand the properties of antimatter, particularly antihydrogen. The subproject of the ALPHA experiment, the ALPHA-g experiment, aims to study antihydrogen in gravity by releasing its atoms from a magnetic trap; this trap is essential so it does not annihilate.

It is important to note that most of the antihydrogen atoms are moving too fast to be captured in the magnetic trap, and only a few get captured; thus, they do this process many times to get a measurable quantity of them trapped in the magnetic trap. They then observe their behaviour under gravity by releasing them from the trap. When doing this with normal hydrogen, 80% of it falls, and they hoped to see the same percentage with antimatter.

The scientists at CERN’s ALPHA experiment published their observations on September 27, 2023, confirming that antimatter does experience a gravitational force similar to ordinary matter, and approximately 80% of them fell upon experimentation. This result aligns with the existing theories mentioned above. This is not the end of the story, and future experiments are focused on finding whether antimatter falls at the same rate as regular matter or not.

This was the first attempt to drop antimatter, and it proves what the human race is capable of doing in the future.
This was the first attempt to drop antimatter, proving what the human race can do in the future.

  It is a remarkable feat of science that we have come to the point where antimatter can be created in a lab, contained without annihilation, and then experimented with. CERN’s Antimatter Factory is an extraordinary facility in the world that produces and studies antimatter. Future endeavours for scientists include finding more properties between antimatter and its counterpart. This was the first attempt to drop antimatter, proving what the human race can do in the future.

References:  

Also read: LITTERBUGS IN SPACE: THE NEXT FRONTIER FOR CARBON FOOTPRINTS?

Blue Biotechnology: The secrets of the ocean are yet to be explored

Samra Hayat Khan
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Blue Biotechnology: The secrets of the ocean are yet to be explored

“THE SEA, ONCE IT CASTS ITS SPELL, HOLDS ONE IN ITS NET OF WONDER FOREVER.” -Jacques Cousteau

The marine ecosystem covers about 70 percent of our Earth’s environment. From the smallest marine microorganisms to the largest, the enormous Antarctic blue whale, this percentage comprises a vast diversity of living and non-living things. The world’s population in 2015 was about 7.3 billion, which increased to 7.9 billion in 2021. To meet the needs of this ever-growing population, we need to move towards new sustainable goals that provide basic needs to the people without negatively impacting the environment. 

Blue biotechnology or marine biotechnology is a relatively new field. It utilizes marine biodiversity in terms of chemistry, physiology, and marine organisms. Unfortunately, the marine ecosystem remains the most under-explored, under-studies, and under-utilized, even with so many beneficial properties. 

POTENTIALS OF BLUE BIOTECHNOLOGY

Science and technological improvements have made it easier for marine biotechnology to be applied in various industries, from food and feed to biomedical research and pharmaceuticals (Rotter et al., 2021). Marine biotechnology involves the production of commodities and processes obtained from marine creatures using technologies such as biotechnology, molecular and cellular biology, and bioinformatics. 

This field is fascinating both scientifically and commercially. There are no ecosystems on the Earth that can provide greater genetic diversity for creating new commodities and processes than the marine environments. The marine ecosystem is undeniably enriched with many sources for compounds that have great importance in biotechnology (Thakur & Thakur, 2021).

Following are a few areas where blue biotechnology is beneficial:

PHARMACEUTICALS

Exploration of the marine ecosystem revealed evidence of various compounds derived from marine species, unraveling the application of marine biotechnology in the pharmaceutical sector. Marine natural compounds have up to four times the success rate of other naturally produced substances, making them a valuable source in medication development (Sigwart, Blasiak, Jaspars, Jouffray & Tasdemir, 2021).

These compounds are being used as antioxidants, antibiotics, analgesics, anti-cancer, anti-inflammatory, and antifungal medicines in the pharmaceutical sector (Mayer et al., 2019). Some FDA-approved medications based on marine biotechnology include YondelisR, PrialtR analgesic, and antitumor agent Cytosar-UR (Martins, Vieira, Gaspar & Santos, 2014).

NUTRACEUTICALS 

Due to the growing population and dwindling agricultural food production, a considerable amount of food must be generated from ecologically favorable marine alternatives. (Olsen, 2011). Marine biotechnology, for instance, is extensively used to extract minerals, fibers, and secondary metabolites from macro-, micro-, and cyanobacteria for use as dietary nutrients or nutraceutical supplements. 

Fish are known to have established antioxidant and cardioprotective properties due to omega-3 fatty acids (Suleria, Osborne, Masci & Gobe, 2015). Thus, marine biotechnology is critical for assisting in resolving the worldwide crisis of health and nutrition. 

Fish are known to have established antioxidant and cardioprotective properties due to omega-3 fatty acids
Fish are known to have established antioxidant and cardioprotective properties due to omega-3 fatty acids.

COSMETICS AND COSMECEUTICALS

Marine biotechnology contributes significantly to the cosmetics sector by introducing novel substances into cosmetics formulation with additional health benefits that attract people’s attention. Several marine-based cosmetics have been obtained biotechnologically and are now on the market (Guillerme, Couteau & Coiffard, 2017). 

Compounds used in cosmetic formulations are often isolated from microalgae or other marine organisms and then grown in photo-bioreactors. For instance, these components may be employed as antioxidants, gels, pigments, and other ingredients in skincare and hair care products. (Alves, Sousa, Kijjoa & Pinto, 2020). 

Although several firms in the cosmetics industry, such as Mibelle BiochemistryR and GreenaltechR, fund marine biotechnology, there is relatively limited scientific evidence in this field (Barcelos, Lupki, Campolina, Nelson & Molina, 2018). Hence, research in this area should be promoted to enhance manufacturing procedures and the use of marine organism-derived chemicals.

BIOMATERIALS 

Marine biomaterial is an ever-growing topic of study with substantial applications in industry, health, agriculture, biofuels, bioenergy, and other sectors. Despite industrial pollution, overfishing, and unforeseen climate change, marine biomaterials are plentiful. Marine biomaterials, including polysaccharides, bioceramics, enzymes, peptides, lipids, and nanoparticles, have a broad spectrum of biocompatibility. 

Harvesting marine biomaterials is integral to the application of marine biotechnology. Marine biomaterials are a great alternative to traditional materials due to their extensive biocompatibility and ability to biodegrade with little to no side effects. Globally, marine biomaterials have established a strong market position and are attracting a broad spectrum of marine researchers and customers (Ali, Mir, Hyder & Yang, 2020). 

BIOFUELS 

Marine biofuels are obtained from micro and macro algae and therefore have evolved as a potential substitute for terrestrial ecosystems. Marine biofuel produces 10-100 times increased yields than traditional biofuels obtained from the terrestrial ecosystem. 

Marine biofuels are obtained from micro and macro algae and therefore have evolved as a potential substitute for terrestrial ecosystems.
Marine biofuels are obtained from micro and macro algae and therefore have evolved as a potential substitute for terrestrial ecosystems.

Bioethanol, often referred to as 3 G ethanol, is the most widely synthesized biofuel using marine biotechnology. It is created from algae biomass (John, Anisha, Nampoothiri & Pandey, 2011). The energy produced from algae has considerable advantages, including minimal land usage; it does not impact agricultural production, and technologies with minimum costs are now being established.

Further, it is anticipated that biofuel generation would efficiently and successfully eliminate reliance on imported fuels. Utilizing microalgae’s capability to produce biofuel in Pakistan might help the nation become energy self-sufficient. 

Even though Pakistan’s government has established many entities to nurture and facilitate alternative energy sources and achieve a 10% profit margin of biofuels in the energy industry by 2020, the goals have yet to be accomplished on ground levels (Shah et al. 2018).

FUTURE ASPECTS

Food security and world hunger are among the most recurring issues for developing nations. Amidst such problems, biotechnology is paving different ways and technologies to cope. 

It offers promising, exciting, and environmentally friendly alternatives to meet the consumer demands for the sustainable development of agriculture. Biotechnology has different applications that can significantly impact and resolve world hunger by revolutionalizing fertility, agricultural biotechnology, and wellbeing. 

As Mike Pompeo said:

“Feeding the world will be one of the greatest challenges of the 21st century. It will be impossible without using scientific advancements and biotechnology.”

REFERENCES

Ali, M., Mir, S., Hyder, M., & Yang, W. (2020). Harvesting of Bioenergy and Biomaterials from Marine Resources. Encyclopedia Of Marine Biotechnology, 711-736. DOI: 10.1002/9781119143802.ch27

Alves, A., Sousa, E., Kijjoa, A., & Pinto, M. (2020). Marine-Derived Compounds with Potential Use as Cosmeceuticals and Nutricosmetics. Molecules, 25(11), 2536. DOI: 10.3390/molecules25112536

Barcelos, M., Lupki, F., Campolina, G., Nelson, D., & Molina, G. (2018). The colors of biotechnology: general overview and developments of white, green, and blue areas. FEMS Microbiology Letters, 365(21). DOI: 10.1093/female/fny239

Guillerme, J., Couteau, C., & Coiffard, L. (2017). Applications for Marine Resources in Cosmetics. Cosmetics, 4(3), 35. doi: 10.3390/cosmetics4030035

John, R., Anisha, G., Nampoothiri, K., & Pandey, A. (2011). Micro and macroalgal biomass: A renewable source for bioethanol. Bioresource Technology, 102(1), 186-193. DOI: 10.1016/j.biortech.2010.06.139

Martins, A., Vieira, H., Gaspar, H., & Santos, S. (2014). Marketed Marine Natural Products in the Pharmaceutical and Cosmeceutical Industries: Tips for Success. Marine Drugs, 12(2), 1066-1101. DOI: 10.3390/md12021066

Mayer, A., Guerrero, A., Rodríguez, A., Taglialatela-Scafati, O., Nakamura, F., & Fusetani, N. (2019). Marine Pharmacology in 2014–2015: Marine Compounds with Antibacterial, Antidiabetic, Antifungal, Anti-Inflammatory, Antiprotozoal, Antituberculosis, Antiviral, and Anthelmintic Activities; Affecting the Immune and Nervous Systems, and Other Miscellaneous Mechanisms of Action. Marine Drugs, 18(1), 5. doi: 10.3390/md18010005

Olsen, Y. (2011). Resources for fish feed in future mariculture. Aquaculture Environment Interactions, 1(3), 187-200. DOI: 10.3354/aei00019

Shah, S., Raja, I., Rizwan, M., Rashid, N., Mahmood, Q., Shah, F., & Pervez, A. (2018). Potential of microalgal biodiesel production and its sustainability perspectives in Pakistan. Renewable And Sustainable Energy Reviews, 81, 76-92. DOI: 10.1016/j.rser.2017.07.044

Rotter, A., Barbier, M., Bertoni, F., Bones, A., Cancela, M., & Carlsson, J. et al. (2021). The Essentials of Marine Biotechnology. Frontiers In Marine Science, 8. doi: 10.3389/fmars.2021.629629

Sigwart, J., Blasiak, R., Jaspars, M., Jouffray, J., & Tasdemir, D. (2021). Unlocking the potential of marine biodiscovery. Natural Product Reports, 38(7), 1235-1242. DOI: 10.1039/d0np00067a

Suleria, H., Osborne, S., Masci, P., & Gobe, G. (2015). Marine-Based Nutraceuticals: An Innovative Trend in the Food and Supplement Industries. Marine Drugs, 13(10), 6336-6351. DOI: 10.3390/md13106336

Thakur, N., & Thakur, A. (2021). Marine biotechnology: An overview. Retrieved 19 December 2021, from http://nopr.niscair.res.in/handle/123456789/7759

Metaverse and Pakistan– Merging the Parallel Worlds

Sarah Arif
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Metaverse and Pakistan– Merging the Parallel Worlds

The unprecedented takeover of the COVID-19 pandemic caused the downfall of several industries, yet it bloomed the digital world quickly. Humans have created a real-life version of a digital world known as the Metaverse. 

Photo Credits: voicebot.ai
Photo Credits: voicebot.ai

Meta, formerly Facebook, aims to extend its services beyond a 2D interface and towards an innovative 3D space to create more meaningful connections. People can experience the Metaverse through various ways, including Virtual Reality (VR), Augmented Reality (AR) and Artificial Intelligence (AI).

Although the online gaming world has dominated the Metaverse, it is much more than that. If executed successfully to the mass audience, Metaverse can change the traditional nine-to-five office lifestyle. It will allow people to free themselves from the shackles of an office routine and let them work remotely.   

According to published research in 2023 called “Digital Business Model Innovation in Metaverse: How to Approach Virtual Economy Opportunities”, the change in the name of ‘Facebook’ to ‘Meta’ shows the significance of the digitalized universe. 

Famous AI Assistants Photo Credits: Meta
Famous AI Assistants Photo Credits: Meta

Meta recently introduced AI versions of known personalities such as Kendall Jenner and Mr. Beast. This feature allows users to chat with these AI bots who have a name, personality and background story. It has met with significant criticism amongst some people on Instagram, who have labelled this as ‘creepy’ and said this further disconnects real and meaningful interactions. Additionally, Meta has accepted that the information provided by these AI characters may be outdated as it is before 2023, and further improvements will be made with time. 

However, the Metaverse is not limited to social media platforms. It extends to companies selling physical products, such as Coca-Cola, Dyson and IKEA, who have already invested in the Metaverse. The increased interest of considerable corporations in virtual reality is a good enough reason to understand its impact on our future. 

The economic aspects of the Metaverse 

Much like the real world, no human being owns the Metaverse. It simply consists of different technologies and companies. People, therefore, are needed to buy, sell, operate and maintain parts of this digital world. In an article published by Gartner, a management consulting company, Jackie Wiles writes that the Metaverse will run on digital currency and non-fungible tokens (NFTs). Unlike Bitcoin or another cryptocurrency, NFTs cannot be replaced with another NFT. Although anyone can access and print the NFTs bought, it gives the owner of NFTs full rights to the original digital work.

Not long ago, some were suspicious of the emergence of digital currency, whereas others quickly invested in it and promoted this idea. Despite the constant change in the economic value of digital currencies, it can be used in the Metaverse. After all, the physical currency we use today also changes in value in the real world.

A while back, Damac, a real-estate company based in the UAE, invested $100 million in the Metaverse. One might think that such a massive investment in a developing idea is a bold step, but not Damac. Upon financial considerations, the company is optimistic about the outcome. 

 According to their estimations, the current monthly sales of $27.2 million can be multiplied by seven to eight times with this investment. They aim to expand their sales to customers worldwide through the Metaverse. That is, anyone sitting anywhere in the world can experience a virtual property tour and potentially purchase it with NFTs.

Depending on the product or service, respective companies have different plans for fitting themselves into this new universe. So, what is Pakistan’s goal?

Dawn News uploaded paid content on 20th October 2022, which advertised Pakistan’s first ever Metaverse start-up called “The Cloud City Metaverse”, or TCCM. This is a newly launched business, co-founded by Umer Abbas, where users can play in a virtual world free of charge.

A Digitalized Pakistan?  

I tried to find research papers to understand Pakistan’s stance on this hot topic. Upon searching, I found zero published research that discusses the Metaverse and Pakistan in the same article; this is concerning. As the world promotes and invests in the Metaverse, Pakistan is not even in the picture’s background.  

A 2015 research paper, “Design Consideration of Online Shopping Website to Reach Women in Pakistan”, published in the Procedia Manufacturing journal, shares that Pakistan ranks second as the world’s leisurely adopter of online shopping. 

Another research, “Impact of Factors on Consumer’s Decision-Making Process for Online Shopping in Pakistan”, published by Salahuddin and Tahir (2021) in the Journal of Economic Development, Management, IT, Finance and Marketing, informs that the State Bank of Pakistan reported a 93.7% rise in the e-commerce sales of Pakistan as of 2018. This significant increase is due to the availability of the Internet to a larger population.

Editing Sarah Arif via canva.com
Editing Sarah Arif via canva.com

This country is home to many diverse shops. What if these stores opened up in the Metaverse and ultimately brought in customers in this universe as well? It will also introduce foreigners to famous and unique Pakistani items they can buy. That being said, enabling residents to invest and adapt to the Metaverse before it is too late is an issue that needs to be resolved.  

In September 2022, Dawn News published an article titled, “The Metaverse opens up a world of possibilities for Pakistan. Can we take advantage?” The author, Hassan Baig, criticises Pakistan’s non-existent presence in this new era of technology and gives good initiatives it should take in the Metaverse. He emphasizes the government to do its honest part in promoting and establishing services in the Metaverse safely.

Moreover, Baig also shares various ways of utilizing the digital world in Pakistan. He suggests renowned Pakistani universities should offer courses in the Metaverse where world-renowned educators can teach. This approach will prepare undergraduates to tackle the digital world once they enter the corporate world. He also mentioned how Pakistan could effectively use the Metaverse, including investments in real estate, fashion outlets, security, crisis relief and skills training.

Furthermore, Dawn News uploaded paid content on 20th October 2022, which advertised Pakistan’s first ever Metaverse start-up called “The Cloud City Metaverse”, or TCCM. This is a newly launched business, co-founded by Umer Abbas, where users can play in a virtual world free of charge. At the same time, players can customize and own virtual infrastructure if they buy NFTs. Moreover, TCMM has also been invited to attend the Dubai Metaverse Assembly, among other international events, where it has received appreciation for its work.

The End is Near 

The reign of the Metaverse is approaching with the introduction of every new technology. On the one hand, business owners and investors are keen on spending millions of dollars to expand and actualize the digitalized universe. Many employees would be happy to return to working from home, which is one of the dreams that the Metaverse aims to meet. An open and easily accessible worldwide market further enhances the available opportunities for merchandisers and consumers.

A 2023 article titled “Digital Business Model Innovation in Metaverse: How to Approach Virtual Economy Opportunities” in the Journal of Information Processing & Management predicted that the metaverse market could be worth $13 trillion by 2030. It would be not very pleasant to know that out of this $13 trillion, not a single penny belongs to Pakistan.

This can be changed if more tech-based start-ups like TCCM are encouraged and funded by the country. Pakistan should adapt its people to the constant change in technology to stay up-to-date and contribute to the advancements in the world.

 Amid the rise of the Metaverse, Pakistan must secure its position as a vital member of the virtual world to promote employment and success amongst its citizens. Nonetheless, the Metaverse is still a relatively new concept that needs to be perfected and understood better before people can entirely rely on it. 

References: 

Also, Read: Pakistan; The Road towards Digitalization

Waging a war against cancer using our fighter cells

Maham Maqsood
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Waging a war against cancer using our fighter cells

Everyone, at some point in their lives, is introduced to a survivor who has suffered through the dreadful ailment – Cancer. Or we may have lost our loved ones and before death, observed them tread through a path that no one wishes to walk. Countless times, we wished to end their suffrage, but at a certain point, everything must be left to fate. In this age of advancement and technological innovation, it is hard to believe that no proper escape from cancer is available yet (with few exceptions). But one area has caught the attention of researchers and scientists who believe it to be the getaway from cancer: Immunotherapy.

Before jumping on what it is, let’s take a minute to appreciate the human body. You don’t have to be a biologist to be able to praise its delicacy and complexity. The human body is beautiful indeed, how nature has endowed us with complete systems to maintain our existence. From growing into an adult to consuming food to making complex decisions, it is a wonder how intricately interconnected these systems are with each other. Anything goes wrong, and our defense system jumps in to revert everything to normal. But as the saying goes: Nothing is perfect. Sometimes, our cells change so drastically that they can’t stop multiplying, and this uncontrolled abnormal growth is what we call ‘Cancer.’

The Body Patrol

Over the years, many treatments have been suggested, tried, and tested. But few seem to work given that certain circumstances are provided. Cancer cells are so smart and highly advanced that it is a daunting task to treat them. Cancer is killing millions of people each year; it is a health challenge, complicated to tackle. After trying different treatments, scientists have stumbled upon the powerful weapon we all have; our immune system. Present throughout the body, it gives us resistance and fights harmful infectious agents and diseases. At times we don’t even know about all the battles taking place inside our bodies.

Immunotherapy seeks to trigger and restore the immune system to recognize and confront cancer

One is inclined to think that if it’s efficient, then why cancer cells escape our immune system in the first place? Well, that is because, as mentioned, they are very clever and are our body’s mutated cells, they aren’t recognized as a foreign threat by the immune system. As they progress and develop, they gain the ability to dodge, fight, and gain control over the defenses. Immunotherapy is such a treatment that seeks to trigger and restore the immune system to recognize and confront cancer.

How it works

Certain parts of the immune system are used in various ways to target cancer cells. Either simulation or recognition abilities are provided to make them work par cancer or components are given that aid in the process of destruction. It may vary according to the different types and may work better for some than the others.

In the case of the detection of harmful agents, the body also makes proteins called antibodies that attack specific parts on an infected cell. These ‘monoclonal antibodies’ can be used to mark cells that can then be degraded by the immune system.

Our immune system’s ability to discriminate between native and foreign cells mostly involves T cells, which are a type of white blood cells. There are accelerators and brakes (yes, just like that in the cars) that modulate a balance so that only foreign cells are killed, and no autoimmune destruction of the standard cell occurs. These are manipulated by cancer cells so that they can remain incognito.

James P. Allison and Tasuku Honjo were awarded Noble Prize “for their discovery of cancer therapy by inhibition of negative immune regulation”

In immunotherapy, drugs are used to release these brakes leading to wipeout of dangerous cells. The Noble Prize in Physiology or Medicine 2018 was awarded to scientists James P. Allison and Tasuku Honjo, who discovered the crucial pathways i.e. PD-1 and CTLA-4 that cancer cells use to escape. But by blocking these pathways with antibodies, a response is restored. This treatment is called ‘immune checkpoint therapy.’

Another type of T-cell therapy includes targeting receptors. These are the proteins present on the cell surface which help in recognition, signal transmission and are basically the “eyes and ears of the cell.” Altering the receptors in the cell makes them efficiently recognize cancer cells which are then sought from the entire pool and degraded. This therapy is called Chimeric Antigen Receptor (CAR) T-cell therapy and has been helpful in certain blood cancer treatments. Scientists are researching to understand it better and develop effective therapies.

Non-Specific Immunotherapies are another class that aids the immune cells in their quest to destroy cancer. These can be given during other cancer treatments (such as radiation and chemotherapy) or after their completion. Most common include Interferons and Interleukins. The former slows down and hinders the growth of cancer cells and the latter helps in the production of those that are involved in the fight. The medicinal treatments also have drawbacks as well which may vary from person to person, but common side effects include hair loss, high risk of infection, weight gain, low blood pressure, etc.

Expectations vs. reality

All this sounds very impressive and using one’s defense system is a great idea, but has its limitations and problems. While some may be cured on a miraculous level or experience an everlasting response, other patients may not respond that well to immunotherapy. The majority don’t receive a positive effect and studies have shown that the response rate is 20% with a varying survival rate. To find which cancers are the best enemies of this therapy, extensive research is being conducted and methods are being identified. New immunotherapy approaches include improvements through nanotechnology, precision therapy and many more.

Immunotherapy approaches include precision medicines and therapy
In Precision Therapy drugs are tailored according to the genetic makeup and need of the patient
Image Credit: HYACINTH EMPINADO/STAT

Those who receive it may go through drastically different phases: fine at first, sick later. New side effects may originate confusing both the doctors and patients, and severe toxicities startle researchers. This ‘trial and error’ situation is depressing but necessary. Pressure from big pharma and medical industry to develop effective drugs and treatment against cancer is high leading to the conduction of thousands of trials (in which participation rates also drop now and then) where the researchers aim to explore and find the expectations of others suppress an answer. Challenges arise for oncologists who not only have to work out solutions but also have to convince patients who demand immunotherapy without being aware of its pros and cons, just because they have heard about its miracles.

But this shouldn’t lead to the conclusion that it is rouge role outperforms the benefits. There are success stories as well, and various research institutes around the world are leading the way. Who knows, it may even beat out conventional chemotherapy. But a reality check can help to keep things in place and create a balance between the trend and its potential. Immunotherapy surely has the potential to alter the landscape of cancer treatments and deserves all the praise and attention. It has a long way to go, but hope should keep alive for it can indeed change and save lives of millions of people who have cancer, a feat yet to accomplish.

Did you like that? Then check out The Taboo around Cancer in Women

The Hidden Culprit of Winter Smog- Temperature Inversion

Adnan Mirza
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0
The Hidden Culprit of Winter Smog- Temperature Inversion

As the cold grips the city of Karachi and the rest of the country, everyone is concerned with the smog, but fewer are aware that an important phenomenon and one of the main reasons for smog is known as the “Temperature Inversion Layer”.

The inversions are stable air masses where the warm air overlays the excellent air mass. The more generous top layer creates a blanket over the more excellent air mass below, which seizes the vertical movement of the atmosphere by trapping the cool air mass underneath it, along with all the pollutants suspended in it.

This is precisely the opposite of the typical temperature profile. Hence the name “temperature inversion”. Earth’s atmosphere is divided into layers i.e., troposphere, stratosphere, mesosphere, exosphere, etc. These layers are divided based on their physical parameters, such as temperature and density. In each layer, these parameters change. Usually, the air temperature decreases with increasing height in the troposphere.

In the case of inversion, the temperature gradient behavior inverts i.e., the lower layers of air become cooler than the upper layers. 

thermal invasion

How is it formed?

One of the reasons for temperature inversion to form is when a warm, less dense air mass moves over the cooler and denser air mass. This traps the cool air below the warm air, creating an inversion layer.

Under normal conditions, the lower layers of the air in the troposphere are heated by the radiation emitting from the Earth. The heat then travels upwards via convection and increases the temperature of the upper layers of air in the troposphere. Temperature inversion can also form if the Earth cools rapidly via radiation. This usually occurs during the winter or at night. The air near the Earth’s surface cools along with it. The air above the surface layer does not cool as rapidly as the air near the surface, creating an inversion layer.

Conditions

There are a few conditions for this phenomenon to occur:

  • The first is the temperature. The winter season provides the necessary requirements to trigger an inversion event.
  • Similarly, the time of the day is another factor. The inversion layer occurs during sunrise when the ground has cooled off and starts cooling the air layer near the surface.
  • Strong winds help in the mixing of air masses. During calm weather, the air masses stay stable and do not mix. This increases the chances of an inversion layer occurring.
  • Similar to the wind effect, precipitation also helps in the mixing and moving of air masses. Lack of rainfall allows stable air masses to exist, contributing to the inversion layer events.
  • Additionally, the topography plays an important role in this. Cool air sinks at the bottom of the valleys and depressions, increasing the possibility of an inversion layer.
A depiction of how pollutants get trapped due to inversion. Credits: University of Missouri.
A depiction of how pollutants get trapped due to inversion. Credits: University of Missouri.

Types of Inversions

There are four kinds of inversions: ground, turbulence, subsidence, and frontal.

Ground Inversion: The air near the surface cools rapidly due to the cooling of the Earth’s surface. The upper layers remain warmer than the bottom layer. Additionally, if the temperature of the bottom layer reaches the dew point, fog will form.

Moreover, in hilly areas, the cool air sinks from the hill slopes toward the bottom, creating an inversion layer.

Turbulence Inversion: This occurs when a turbulent air mass is overlain by static or calm air mass. Turbulent air mass loses heat due to mixing, whereas the static air mass remains warm.

Subsidence Inversion: Due to high pressure, the air descends rapidly from a higher altitude and heats up due to compression. The air at the bottom remains cooler, hence creating an inversion layer.

Frontal Inversion: This type of inversion happens when a warm air mass overlays a cool air mass. The difference in their densities doesn’t allow mixing; therefore, the warm front, being less dense, wedges over the cool front.

frontal inversion
Frontal Inversion

The Problem

In normal circumstances, the vertical movement of the air persists, which allows the mixing and dispersion of the air. In the case of temperature inversion, warm air rises, trapping the cool air underneath it. This seizes the vertical motion of the air. This also traps the smoke and pollutants from escaping. These particles don’t move because the airflow is blocked. The particles then combine to become even more lethal, leaving behind persistent, dangerous smog.

In the northern hemisphere, inverse temperatures are more frequent in the winter. Additionally, burning wood or coal in homes for heat increases air pollution by releasing more dangerous contaminants into the atmosphere. Increased pollution combined with the inversion mechanism is the perfect recipe for respiratory diseases among people. Diseases such as sore throat, conjunctivitis, and lung irritation are a few common issues related to being in so much polluted air.

Understanding the Temperature Inversion Layer is crucial in addressing the air quality challenges that arise during winter. Efforts to mitigate pollution should consider these atmospheric intricacies. Whether it’s promoting cleaner energy sources, regulating industrial emissions, or fostering awareness about the impact of individual activities, acknowledging the role of temperature inversion is a vital step toward breathable and healthier urban environments.

As we navigate the winter season, it’s not just about bundling up against the cold; it’s about unraveling the layers of atmospheric complexities that impact our health and well-being. By unveiling the secrets behind temperature inversion, we can make informed decisions that contribute to cleaner air and a safer environment.

References:

Met Office

Read more: SUSTAINABILITY IN ASTRONOMY — A CONVERSATION WITH DR LEONARD BURTSCHER FROM “ASTRONOMERS FOR PLANET EARTH”

Cow burps heat up the Earth; Biotech company invents Bovine Beano

Rebah Tanvir
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0
Cow burps heat up the Earth; Biotech company invents Bovine Beano

Cows burp out Methane, which is 34 times more potent than carbon dioxide among the greenhouse gases that heat up the world. A biotech startup, Lumen Bioscience, based in Seattle, has come forward with a solution to this problem. An enzyme—made of spirulina breaks down the microorganism responsible for reducing these emissions at a low cost.

Methane — a hot gas

Greenhouse gases help maintain the temperature of the Earth; they are a combination of carbon dioxide, methane, ozone, nitrous oxide, chlorofluorocarbons, and water vapour. Methane is a greenhouse gas released during the breakdown of organic substances, for example, in the gastrointestinal tract of animals. Researchers at Wageningen University have found Ruminants (cows, goats, sheep) to be a particular source of much methane.

Agriculture is also known to be the predominant source of methane. In fact, according to data from the United States National Oceanic and Atmospheric Administration, even as carbon dioxide emissions decelerated during the pandemic-related lockdowns of 2020, atmospheric methane shot up. Sustainable development has become a crucial step to combat global warming and reduce carbon footprints that heat the Earth. Companies are finding effective strategies to take part in this initiative.

Lumen to the Rescue

Lumen Biosciences, a biotech start-up based in Seattle, is dedicated to producing cost-effective and patented biologic drugs to cure gastrointestinal diseases in the human gut using spirulina. One such product is the study on bacteria C. difficile to treat recurrent infections in the human gut. 

This technique inspired the researcher at Lumen, Mark Heinnickel, who had grown up on a dairy farm, to realize that if the same basic approach targeted methane-producing bacteria, it might help cows’ climate problem. In an interview for Fast company, he said, “He realized if we can kill the C. difficile bacterium that causes human suffering, maybe we can make the same class of enzymes, feed it to cows, and stop methane,” this can in turn, potentially help reduce the greenhouse effects, as methane is 20 times more potent than carbon dioxide.

Credits: Lumen Biosciences. Mesfin Gewe, senior scientist at Lumen Bioscience, holds a dish filled with powdered spirulina cells, each with a therapeutic protein payload. To target methane gas, the spirulina will have been engineered to express the methanogen-targeting lysin protein. Once in the cow rumen, the protein will destroy the methanogen microbes.
Mesfin Gewe, senior scientist at Lumen Bioscience, holds a dish filled with powdered spirulina cells, each with a therapeutic protein payload. To target methane gas, the spirulina will have been engineered to express the methanogen-targeting lysin protein. Once in the cow rumen, the protein will destroy the methanogen microbes. Credits: Lumen Biosciences.

Spirulina is an edible algae that is considered to be a valuable tool in the making of biological medication if only it could be engineered. Researchers at Lumen Biosciences are the only company with successfully engineered spirulina and commercially produced viable, orally administered patent biologics at low cost. They have a large-scale manufacturing process contrary to traditional medication, which uses conventional methods like mammalian cells or injections, and they take pride in the efficacy and high yield of their product.

Other companies have suggested using seaweed supplements to treat the exact cause. Still, there are health and safety concerns regarding additives like bromoform, a potential carcinogen found in the plant, in addition to low yield and high costs. Using spirulina avoids such concerns as feeding the cows spirulina containing the enzyme does not in any way get absorbed in the cow’s bloodstream or milk.

While addressing the fast company, Lumens CEO Brian Finrow assured that the technology used and the enzyme lysin work like a sniper rifle that only targets harmful microbes. He also compared the product to Beano, an enzyme that humans take as a supplement to reduce gas.

Credits: Lumen Biosciences. The powdered spirulina can be pressed into a capsule or pelletized to be taken orally.
The powdered spirulina can be pressed into a capsule or pelletized to be taken orally. Credits: Lumen Biosciences.

Wilkes Center Climate Prize of $1.5M awarded to Lumen Biosciences

The University of Utah recognized Lumen for its groundbreaking proposal to significantly reduce methane emissions from cattle using a patented enzyme mixture. This innovative approach outshone 77 international competitors and holds the potential to revolutionize climate change mitigation efforts. 

Lumens CEO Brian Finrow and Chief Scientific Officer Jim Roberts founded Lumen with the vision of revolutionizing protein therapeutics manufacturing, enabling them to address global challenges that conventional biomanufacturing technologies cannot tackle. The recognition bestowed by the Wilkes Climate Prize at the University of Utah serves as a powerful affirmation of Lumen’s commitment to making a positive impact on the world.

William Anderegg (right), director of the Wilkes Center for Climate Science and Policy, awards the inaugural Wilkes Climate Prize at the University of Utah to Jim Roberts, chief scientific officer at Lumen Bioscience. Photo credit: Todd Anderson/University of Utah College of Science.
William Anderegg (right), director of the Wilkes Center for Climate Science and Policy, awards the inaugural Wilkes Climate Prize at the University of Utah to Jim Roberts, chief scientific officer at Lumen Bioscience. Photo credit: Todd Anderson/University of Utah College of Science.

It is important to note that these drugs are in the development phases and have promising lab results. Researchers at Lumen suggest one supplement a week for cows once all trials are successful. In an interview with Fast Company, Joseph McFadden, a professor of dairy cattle biology at Cornell University, said, “Clinical efficacy and safety trials are needed for that kind of technology.”

Lumen plans on launching the Rumen biosciences company if the drug trials on cows are thriving, along with approvals from the governments, for example, the FDA. Their patented enzyme mixture will target methane-producing microorganisms in the rumen, a specialized compartment of the cow’s digestive system. This groundbreaking technology, developed by Lumen’s highly skilled scientists, has the potential to mitigate cattle’s contribution to climate change significantly.

References

FAQ: What is the greenhouse effect? (n.d.). Climate Change: Vital Signs of the Planet. Retrieved 4 November 2023, from https://climate.nasa.gov/faq/19/what-is-the-greenhouse-effect

Lumen Bioscience wins historic $1.5M Wilkes Center Climate Prize—@theU. (n.d.). Retrieved 4 November 2023, from https://attheu.utah.edu/facultystaff/wilkes-prize-winner/

Methane emissions are driving climate change. Here’s how to reduce them. (2021, August 20). UNEP. http://www.unep.org/news-and-stories/story/methane-emissions-are-driving-climate-change-heres-how-reduce-them

Muizelaar, W., Groot, M., Duinkerken, G. van, Peters, R., & Dijkstra, J. (2021). Safety and transfer study: Transfer of bromoform present in asparagopsis taxiformis to milk and urine of lactating dairy cows. Foods, 10(3), 584. https://doi.org/10.3390/foods10030584

Peters, A. (2023, September 26). Cows burp out too much methane. This biotech startup is making a bovine Beano. Fast Company. https://www.fastcompany.com/90957325/cow-burps-methane-biotech-startup-enzyme-bovine-beano

PPT – Intergovernmental Panel on Climate Change (IPCC) PowerPoint Presentation—ID:4766348. (n.d.). Retrieved 5 November 2023, from https://www.slideserve.com/morty/intergovernmental-panel-on-climate-change-ipcc

The Greenhouse Effect | Center for Science Education. (n.d.). Retrieved 4 November 2023, from https://scied.ucar.edu/learning-zone/how-climate-works/greenhouse-effect

Also Read: BREAKING THE ODDS IN FIELD EPIDEMIOLOGY IN PAKISTAN

Tales of Women Pioneers in Astronomy: From Aprons to Space

Aly Gajani
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Tales of Women Pioneers in Astronomy: From Aprons to Space

Astronomy, like many fields of science, has historically been male-dominated. From the ancient stargazers of Greece to the renowned astronomers of the Renaissance, women were often relegated to the periphery and denied the opportunities to explore the cosmos. This was not due to a lack of talent or interest among women but rather the systematic barriers they faced in accessing education and pursuing scientific careers.

Before 1900, women interested in studying the stars needed a male relative (father, brother, or husband) to gain access. Even well into the 20th century, despite their significant intellectual abilities, women astronomers faced barriers preventing them from seizing opportunities. This was the reality faced by women who wanted to pursue a career in astronomy.

They were often excluded from educational opportunities, denied funding for their research, and passed over for promotions. Despite these challenges, many women persevered and made significant contributions to astronomy.

Maria Mitchell was one of the earliest women to break through these barriers. Her father encouraged her love of astronomy and helped her to build her own telescope. Mitchell made her first astronomical discovery in 1847 when she spotted a new comet, which made her an international celebrity.

The culture in astronomy and science, in general, has evolved since then. There has been a growing awareness to promote gender equality and inclusion in science. This movement has increased the number of women studying astronomy and a greater recognition of their contributions to the field.

Ekta Patel, a Miller postdoctoral fellow at UC Berkeley who studies satellite galaxies, says, “We don’t want to change ourselves to fit the mould.” Lia Medeiros, an NSF postdoctoral fellow at the Institute for Advanced Study, Princeton, agrees, “I enjoy being a girl. I’m going to be a girl all over their physics. This is my world, too.”

Let us embark on a journey as we appreciate the outstanding achievements of women astronomers who shattered gender norms, leaving an indelible mark on our comprehension of the cosmos.

Cecilia Payne-Gaposchkin

Eventually, Cecilia became the first woman chair of the astronomy department at Harvard.
Eventually, Cecilia became the first woman chair of the astronomy department at Harvard.

She was starting with the inspiring story of Cecilia Payne-Gaposchkin, an American astrophysicist who proposed that stars were composed primarily of hydrogen and helium. In 1925, with her thesis entitled “Stellar Atmospheres,” she became the first to earn a PhD in astronomy from Radcliffe College of Harvard University. Her claims were contrary to prevailing beliefs, so her doctoral thesis was not taken well.

In those times, male astronomers dominated at the highest level; as a result, Payne-Gaposchkin faced a long struggle to gain recognition. She taught several astronomy courses, but her contribution went unlisted in the course catalogues, and they paid her as much as a technical assistant. Despite gender bias affecting her career, she remained persistent.

A few years after her Ph. D., independent researchers verified her research on the composition of stars. Eventually, Cecilia became the first woman chair of the astronomy department at Harvard. Even today, her thesis stands as the cornerstone of astrophysics textbooks, and her lifelong inspirational contributions continue to motivate generations of women to follow.

Henrietta Swan Leavitt

Henrietta Leavitt established the basis for measuring distances in the universe.
Henrietta Leavitt established the basis for measuring distances in the universe.

Like Cecilia, Henrietta Leavitt worked as a ‘computer’ at the Harvard College Observatory to analyze the enormous volume of data the observatory collected. Women were hired as they accepted lower wages. Even college-educated women were paid like unskilled workers, at 25 to 50 cents an hour.

Battling all the gender discrimination, Leavitt went on to discover the properties of Cepheid variable stars that gave astronomers the first ‘standard candle’ to work with, a means to measure the distance to faraway galaxies. Today, as we map the night sky in extensive sky surveys, Henrietta Leavitt established the basis for measuring distances in the universe.

“I am proud of the work that I have done at NASA. I believe that I have made a real difference in astronomy. I hope my work will inspire other women to pursue careers in science.”

Nancy Grace Roman— The Mother of Hubble

She earned her Ph.D. in astronomy from the University of Chicago in 1949, breaking barriers as one of the few women in her cohort.
She earned her Ph.D. in astronomy from the University of Chicago in 1949, breaking barriers as one of the few women in her cohort.

Nancy Grace Roman was a visionary leader who paved the way for the Hubble telescope and beyond. Born on May 16, 1925, in Nashville, Tennessee, Nancy Grace Roman’s fascination with the night sky began at an early age. Encouraged by her parents, she pursued her love for astronomy and mathematics. Roman’s journey in a male-dominated field was marked by resilience and brilliance. She earned her Ph.D. in astronomy from the University of Chicago in 1949, breaking barriers as one of the few women in her cohort.

In 1959, Roman joined NASA as the first chief of astronomy, where she played a vital role in the planning and development of the Hubble Space Telescope. In her own words, in an interview, she said, “I am proud of the work that I have done at NASA. I believe that I have made a real difference in astronomy. I hope my work will inspire other women to pursue careers in science.”

Katherine Johnson

Her career began in 1953 when she joined NASA, where she was a "computer" at Langley Research Center "when the computer wore a skirt," Katherine once said.
Her career began in 1953 when she joined NASA, where she was a “computer” at Langley Research Center “when the computer wore a skirt,” Katherine once said.

In the chronicles of space exploration, the name Katherine Johnson shines like a brilliant star. Her remarkable contributions to NASA, particularly during the Apollo program, remain an inspiring testament to the power of intellect, perseverance, and breaking down racial and gender barriers. Her career began in 1953 when she joined NASA, where she was a “computer” at Langley Research Center “when the computer wore a skirt,” Katherine once said.

She was involved in calculating trajectories for numerous space missions, most notably for John Glenn’s historic orbit of the Earth in 1962. Her precise calculations were crucial in ensuring Glenn’s safe return. Yet, her most monumental role was in the Apollo program, where her brilliance and expertise in plotting the spacecraft’s trajectory provided the safe arrival of the first human Moon landing.

Katherine Johnson’s contributions did not go unnoticed. Over the years, her groundbreaking work received the recognition it deserved. In 2015, she was awarded the Presidential Medal of Freedom, the nation’s highest civilian honour, by President Barack Obama.

Vera C. Rubin

She received several profound awards, including the National Medal of Science and the Gold Medal of the Royal Astronomical Society.
She received several profound awards, including the National Medal of Science and the Gold Medal of the Royal Astronomical Society.

Vera Rubin stands as an iconic figure in the world of astrophysics. She led the revolutionary research, which offered the initial direct proof of the presence of Dark Matter, the enigmatic substance constituting most of the universe yet emitting neither energy nor light.

Unfortunately, all women astronomers in those times—those earning doctorates between the mid-1950s and the mid-1980s—had the same stories of gender discrimination. Rubin’s early contributions were met with scepticism from her fellow colleagues in the field, to the extent that she was advised to stay away from science. She kept going anyway by telling herself she was just different from other people.

Ultimately, like many women astronomers, she gained recognition only through her significant contributions to the field. Her groundbreaking work on the rotation curves of galaxies played a crucial role in our understanding of galaxy formation and modern cosmology.

She received several profound awards, including the National Medal of Science and the Gold Medal of the Royal Astronomical Society. Indeed, her contributions to science serve as a beacon of inspiration, especially for women, to pursue careers in astrophysics.

“The fact that I was a graduate student and a woman, together, demoted my standing in receiving a Nobel Prize.”

Jocelyn Bell Burnell

"Women should not have to do all of the adapting."
“Women should not have to do all of the adapting.”

As part of her doctoral research at Cambridge University, Jocelyn Burnell was responsible for operating a radio telescope with her adviser, Antony Hewish, and Sir Martin Ryle, where they observed strange pulsating signals coming from space. After careful investigation, she and her colleagues determined that these radio signals were emitted by a rapidly rotating neutron star, which became known as a pulsar.

Burnell was the second author of the paper announcing the discovery of pulsars, but she was not awarded the Nobel Prize in Physics, which was jointly awarded to Hewish and Ryle in 1974. In later years, she finally said, “The fact that I was a graduate student and a woman, together, demoted my standing in receiving a Nobel Prize.”

Ekta Patel, a Miller postdoctoral fellow at UC Berkeley who studies satellite galaxies, says, “We don’t want to change ourselves to fit the mould.”

Despite this setback, Burnell continued her pioneering work in astrophysics and has received numerous awards and honours for her contributions to astronomy. She was named the first female president of the Royal Society of Edinburgh. She has been a strong advocate for women in science as well. 2018, she was awarded the Breakthrough Prize in Fundamental Physics, worth three million dollars (£2.3 million). She donated all the money to fund women’s scholarships and under-represented ethnic minority and refugee students to become physics researchers.

She inspires scientists and aspiring researchers worldwide, reminding us that groundbreaking discoveries can come from anyone, regardless of their background or gender. Her own words, “Women should not have to do all of the adapting. It is time for society to move towards women, not women towards society,” conveys a profound source of inspiration.

Andrea Ghez

Among the other four female Nobel Laureates in physics, Ghez is the only astronomer.
Among the other four female Nobel Laureates in physics, Ghez is the only astronomer.

Andrea Ghez’s journey in astrophysics began at a young age, inspired by her father’s love for astronomy. She pursued her passion by obtaining her Bachelor’s degree in Physics from MIT and eventually a Ph.D. in Astronomy from Princeton University. Ghez’s most notable contributions evolve around the study of black holes, particularly at the centre of our Milky Way galaxy.

Through years of meticulous observations and data analysis, Ghez and her team were able to provide compelling evidence for the existence of Sagittarius A*, a supermassive Black Hole at our galactic centre. It was a commendable work that led to her recognition within the community. In 2020, she was awarded the Nobel Prize in Physics, sharing the honour with Roger Penrose and Reinhard Genzel. Among the other four female Nobel Laureates in physics, Ghez is the only astronomer.

This implies that the remarkable accomplishments of these women, and many others, transformed the narrative around astronomy to incorporate “women” as an integral part, essentially merging “women” with “astronomy”.

The same spirit of scientific discovery is still alive today, as proven by scientists such as Sara Seager, who has been recognized as one of the most influential figures in modern astronomy by the Times, Popular Science, and Nature. In addition, the admirable work by Katherine Bouman in developing an algorithm for imaging black holes has been groundbreaking.

At the same time, Nergis Mavalvala, an astrophysicist of Pakistani origin, played a crucial role in detecting gravitational waves and currently holds the position of Dean at MIT’s School of Science.

These are just a few examples of the many scientists today who are pushing the boundaries of cultural norms and revolutionizing the field. Their stories inspire all who dream of pursuing a career in science. Even though we are seeing a positive trend in women involved in STEM, they often encounter a lack of appreciation and recognition, uncertain career pathways, and harassment.

Recognizing these challenges, the astronomy community has launched initiatives to honour women in STEM. Organizations like the International Astronomical Union and the American Astronomical Society have created committees promoting diversity, equity, and inclusion.

Additionally, various awards like the Annie Jump Cannon Award in astronomy, the Women in Space Science Award from the Women’s Board of the Adler Planetarium, and the Maria Mitchell Women in Science Award recognize and celebrate the accomplishments of women in the field.

These stories are inspiring and remind us that with passion and determination, anything is possible. They also highlight the ongoing journey towards gender equality in science. We can keep moving towards a future where everyone has a chance to reach their goals. We should celebrate the achievements of women astronomers and encourage more women to join the field. It is a reminder that the sky is for everyone, regardless of gender.

References:

  • Hughes, A. M. (2014). The 2013 CSWA Demographics Survey: Portrait of a Generation of Women in Astronomy. STATUS: A Report on Women in Astronomy, January 2014, 1-9.
  • Dickmann, N. (2017). Women scientists in astronomy and space. Gareth Stevens Publishing LLLP.
  • Finkbeiner, A. (2022). Women Are Creating a New Culture for Astronomy. Scientific American. https://doi.org/10.1038/scientificamerican0422-32
  • Stevens, S. (2021). 10 Female Astronomers Everyone Should Know. Treehugger. https://www.treehugger.com/female-astronomers-everyone-should-know-4864074
  • Green, K. (2023, June 6). Journey to the stars: the personal stories of women in astronomy – Physics World. Physics World. https://physicsworld.com/a/journey-to-the-stars-the-personal-stories-of-women-in-astronomy/
  • Rubin, V. C. (2011). An interesting voyage. Annual Review of Astronomy and Astrophysics, 49, 1-28.

Also, Read: Review: ‘Hidden Figures

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